Chromosome Breakage

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Chromosome breakage and repair.

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Chromosome breakage and ultrasound.

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The Fragile Breakage versus Random Breakage Models of Chromosome Evolution

For many years, studies of chromosome evolution were dominated by the random breakage theory, which implies that there are no rearrangement hot spots in the human genome. In 2003, Pevzner and Tesler argued against the random breakage model and proposed an alternative "fragile breakage" model of chromosome evolution. In 2004, Sankoff and Trinh argued against the fragile breakage model and raised...

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Chromosome breakage following G2 checkpoint release

DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (AT) cells have checkpoint arrest and DSB repair defects. Here, we examine the efficiency and interplay of ATM's G2 checkpoint and repair functions. Artemis cells manifest an identical and epistatic repair defect to AT but show proficient checkpoint ...

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Chromosome breakage after G2 checkpoint release

DNA double-strand break (DSB) repair and checkpoint control represent distinct mechanisms to reduce chromosomal instability. Ataxia telangiectasia (A-T) cells have checkpoint arrest and DSB repair defects. We examine the efficiency and interplay of ATM's G2 checkpoint and repair functions. Artemis cells manifest a repair defect identical and epistatic to A-T but show proficient checkpoint respo...

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ژورنال

عنوان ژورنال: Progress in Biophysics and Biophysical Chemistry

سال: 1954

ISSN: 0096-4174

DOI: 10.1016/s0096-4174(18)30065-9